Leuckart thiophenol reaction

Leuckart thiophenol reaction
Named after Rudolf Leuckart
Reaction type Substitution reaction
Identifiers
Organic Chemistry Portal leuckart-thiophenol-reaction

The Leuckart thiophenol reaction is the decomposition of a diazoxanthate, by gentle warming in a slightly acidic cuprous medium, to its corresponding aryl xanthates which give aryl thiols on alkaline hydrolysis and aryl thioethers on further warming.[1]

This reaction was first reported by Rudolf Leuckart in 1890.[2][3][4]

Key Points

The reaction provides a route to introduce Sulfur into aromatic rings.

Products: Aryl Thiols and Aryl Thioethers.

Cu(I) acts as a catalyst to facilitate the decomposition of the diazo intermediate.

Applications

Preparation of Aryl Thiols (Ar–SH): Important in Pharmaceuticals, Dyes, and Agrochemicals.

Synthesis of Aryl Thioethers (Ar–S–Ar): Used in Polymers, Drugs, Materials Chemistry.

Substitution of Diazonium salts with Sulfur groups, expanding the Sandmeyer-resembling transformations.

References

  1. ^ Kazem-Rostami, Masoud; Khazaei, Ardeshir; Moosavi-Zare, Ahmad; Bayat, Mohammad; Saednia, Shahnaz (2012). "synthesis of thiophenols from related triazenes". Synlett. 23 (13): 1893–1896. doi:10.1055/s-0032-1316557.
  2. ^ Leuckart, Rudolf (30 December 1889). "Eine neue Methode zur Darstellung aromatischer Mercaptane". Journal für Praktische Chemie. 41 (1): 179–224. doi:10.1002/prac.18900410114.
  3. ^ Fukushima, D. K.; Tarbell, D. S. (1947). "m-THIOCRESOL". Organic Syntheses. 27: 81. doi:10.15227/orgsyn.027.0081.
  4. ^ Merck Index 14th Ed.