I noticed that some older version of wine have this bug of doing Alt+Tab loses mouse focus in windows applications running in wine, while newest version of wine don't have this problem.
For example when I was using wine of this version wine-10.0 then I had this Alt+Tab problem.
On the other hand when I installed this "Staging" branch version of wine then this problem got fixed alongside with other problems - wine-10.13 (Staging)
The wine-staging branch version of wine contains some new, experimental patches which haven't yet been integrated into mainstream wine-stable branch of wine. So mainstream, stable version of wine available in default repository of Linux might be a bit outdated and can still contain many bugs unfixed.
Below are the instructions to install wine-staging branch version, which I recommend
# purge former installation of wine
sudo apt remove winehq* wine-stable* wine-devel* wine*
sudo apt purge winehq* wine-stable* wine-devel* wine*
sudo apt autoremove
# install wine staging branch version
sudo dpkg --add-architecture i386
sudo mkdir -pm755 /etc/apt/keyrings
sudo wget -O /etc/apt/keyrings/winehq-archive.key https://dl.winehq.org/wine-builds/winehq.key
# below line is for Linux Ubuntu 24.04 noble numbat, you can adjust it for other versions
sudo wget -NP /etc/apt/sources.list.d/ https://dl.winehq.org/wine-builds/ubuntu/dists/noble/winehq-noble.sources
sudo apt update
sudo apt install --install-recommends winehq-staging
wine --version
# wine-10.13 (Staging)
Then this problem of Alt+Tab should disappear.
For games you can also try using heroic launcher with proton-ge based on wine but customized for gaming, instead of default wine version.
I recommend installing wine prefixes on ext4 partitions, instead of ntfs, fat partitions, because otherwise there can be crashes caused by lack of symbolic links in ntfs, fat partitions.
If above doesn't work then You can also check these other 2 solutions for this problem:
Method 1:
Run winecfg -> Graphics tab -> check all 4 checkboxes especially these 2:
- "Automatically capture the mouse in full-screen windows"
- "Emulate a virtual desktop"
Here it might be advisable to set Desktop size resolution equal to the monitor resolution that is used in Your Linux OS, like 1366x768 both in monitor screen settings and inside this winecfg option.
When both screen resolutions are identical then Window application running in game should fit entire monitor screen just like full screen. If both resolutions aren't identical then there can be undesired results like wine window not filling entire screen - windowed mode.
Method 2:
Another potential workaround to these problems with Alt+Tab is to use 2 different desktop workspaces, 1st for non-wine applications and 2nd for wine applications.
Switch to another desktop workspace and launch wine applications in a separate workspace and then you can switch workspaces with key combinations like these:
Ctrl+Alt+Left / Right
Super key+Page Down / Page Up