Das Protein Cell division cycle 23 homolog (S. cerevisiae), auch CDC23, wird durch das Gen CDC23 kodiert.

Funktion

Das humane Protein CDC23 ist seinem Homologon Cdc23 in S. cerevisiae sehr ähnlich. Das Molekül ist essentiell für das Fortlaufen des Zellzyklus durch den G2-M- Schadenskontrollpunkt. Das Protein ist Bestandteil des Anaphase-promoting complex (APC), der aus 8 Proteinuntereinheiten besteht und in eukaryotischen Zellen hochkonserviert ist. APC katalysiert die Bildung des Cyclin B-Ubiquitinkonjugates, das die Ubiquitin-gesteuerte Proteolyse von Cyclin B bewirkt. Das Protein enthält, wie auch drei weitere Bestandteile des APC-Komplexes, das TPR-Strukturmotiv als Protein-Protein-Interaktionsdomäne.

Interaktionen

Es wurde nachgewiesen, dass CDC23 mit CDC27 interagiert.

Literatur

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Einzelnachweise

  1. 1 2 Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae).
  2. ↑ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM: TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. In: Current Biology. 13. Jahrgang, Nr. 17, September 2003, S. 1459–68, doi:10.1016/S0960-9822(03)00581-5, PMID 12956947.
  3. ↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM: The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. In: Proceedings of the National Academy of Sciences of the United States of America. 97. Jahrgang, Nr. 16, August 2000, S. 8973–8, doi:10.1073/pnas.97.16.8973, PMID 10922056, PMC 16806 (freier Volltext).
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