Isay reaction

The Isay reaction also known as Gabriel-Isay condensation is an organic reaction in which certain diaminopyrimidines are transformed into pterins by condensation with a 1,2-dicarbonyl compound, such as 2,3-butanedione.[1][2] The reaction is named after Oskar Isay.

Isay reaction
Named after Oskar Isay
Reaction type Ring forming reaction

See also

References
  1. Isay, Oskar (1906). "Eine Synthese des Purins". Berichte der Deutschen Chemischen Gesellschaft. 39: 250–265. doi:10.1002/cber.19060390149..
  2. Kaufman, Seymour; Storm, Carlyle B.; Shiman, Ross (1971). "Preparation of 6-substituted pterins via the Isay reaction". The Journal of Organic Chemistry. 36 (25): 3925–3927. doi:10.1021/jo00824a016..


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