Lumière–Barbier method

The Lumière–Barbier method is a method of acetylating aromatic amines in aqueous solutions.[1] Illustrative is the acetylation of aniline. First aniline is dissolved in water using one equivalent of hydrochloric acid. This solution is subsequently treated, sequentially, with acetic anhydride and aqueous sodium acetate. Aniline attacks acetic anhydride followed by deprotonation of the ammonium ion:

Acetate then acts as a leaving group:

The acetanilide product is insoluble in water and can therefore be filtered off as crystals.

See also

References
  1. Clayden; Greeves; Warren (2001). Organic chemistry. Oxford university press. p. 188. ISBN 978-0-19-850346-0.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.